GSC (gene)

Goosecoid homeobox

PDB rendering based on 2dmu.

Available structures
PDB	2dmu

Identifiers

Symbols

GSC;

External IDs

OMIM: 138890 MGI: 95841 HomoloGene: 7744 GeneCards: GSC Gene

Gene Ontology
Molecular function	• DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding
Cellular component	• nucleus • transcription factor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • multicellular organismal development • gastrulation • anatomical structure morphogenesis • dorsal/ventral neural tube patterning • negative regulation of Wnt receptor signaling pathway • forebrain development • middle ear morphogenesis • ear development • muscle organ morphogenesis • embryonic skeletal system morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
95.23 – 95.24 Mb

Chr 12:
105.71 – 105.71 Mb

PubMed search

[1]

[2]

Homeobox protein goosecoid is a protein that in humans is encoded by the GSC gene.^[1]^[2]

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.^[2]

References

^ Blum M, De Robertis EM, Kojis T, Heinzmann C, Klisak I, Geissert D, Sparkes RS (Oct 1994). "Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1". Genomics 21 (2): 388–393. doi:10.1006/geno.1994.1281. PMID 7916327.
^ ^a ^b "Entrez Gene: GSC goosecoid". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=145258.

Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW (2008). "A child with deletion (14)(q24.3q32.13) and auditory neuropathy". Am. J. Med. Genet. A 146 (1): 117–123. doi:10.1002/ajmg.a.32064. PMID 18074379.
Hartwell KA, Muir B, Reinhardt F et al. (2007). "The Spemann organizer gene, Goosecoid, promotes tumor metastasis". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18969–18974. doi:10.1073/pnas.0608636103. PMC 1748161. PMID 17142318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1748161.
Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Namciu SJ, Friedman RD, Marsden MD et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome 15 (3): 162–178. doi:10.1007/s00335-003-2311-y. PMID 15014966.
Foucher I, Montesinos ML, Volovitch M et al. (2003). "Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors". Development 130 (9): 1867–1876. doi:10.1242/dev.00414. PMID 12642491.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Danilov V, Blum M, Schweickert A et al. (1998). "Negative autoregulation of the organizer-specific homeobox gene goosecoid". J. Biol. Chem. 273 (1): 627–635. doi:10.1074/jbc.273.1.627. PMID 9417125.

PDB gallery

2dmu: Solution structure of the homeobox domain of Homeobox protein goosecoid

External links

The Goosecoid Page

GSC (gene)

References

Further reading

External links